Description

n-Methylleucinebenzyl Ester Hydrochloride is a protected amino acid derivative, specifically the benzyl ester hydrochloride salt of N-methylleucine. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis, particularly in peptide chemistry. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, structurally defined intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate N-methylated leucine residues, which can enhance metabolic stability and membrane permeability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new drug candidates with modified pharmacological profiles.
• Bioconjugation: Acts as a precursor for creating specialized linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Useful for synthesizing labeled or tagged peptides for studying biological pathways and protein-protein interactions.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Item	Details
Product Name	n-Methylleucinebenzyl Ester Hydrochloride
CAS No.	2900-39-2
Molecular Formula	C14H22ClNO2
Molecular Weight	271.78 g/mol
Synonyms	N-Methyl-L-leucine benzyl ester hydrochloride; L-Leucine, N-methyl-, phenylmethyl ester, hydrochloride; Benzyl N-methyl-L-leucinate hydrochloride; (S)-Benzyl 2-(methylamino)-4-methylpentanoate hydrochloride; N-Me-Leu-OBzl·HCl; N-Methylleucine benzyl ester HCl; N-Methylleucine benzyl ester hydrochloride salt
EINECS	Contact for details

Quality Control

Our n-Methylleucinebenzyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.