Description

2-Thienyllithium is a highly reactive organolithium reagent, a cornerstone building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the versatile thiophene heterocycle into molecular frameworks, enabling the construction of complex, high-value compounds. This product is essential for R&D and production chemists in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediates: Key reagent for synthesizing thiophene-containing drug candidates, including potential CNS agents, anti-inflammatory, and antimicrobial compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the thiophene moiety enhances biological activity.
• Organic Electronic Materials: Critical for constructing π-conjugated systems in organic semiconductors, OLEDs, and conductive polymers.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene ligands containing thiophene groups.
• Fine Chemical and Specialty Polymer Production: Employed in the synthesis of dyes, pigments, and specialty monomers.
• Cross-Coupling Reactions: A pivotal reactant in metal-catalyzed cross-couplings such as Negishi, Kumada, and Suzuki-Miyaura reactions to form C-C bonds.

Basic Information

Product Name	2-Thienyllithium
CAS No.	2786-07-4
Molecular Formula	C4H3LiS
Molecular Weight	98.06 g/mol
Synonyms	2-Thienyllithium; 2-Lithiothiophene; Thiophen-2-yllithium; Lithium thiophen-2-ide; 2-Thienyl lithium reagent; Thiophene-2-lithium; 2-Thienyllithium solution; Lithiothiophene
EINECS	220-506-9

Quality Control

Our 2-Thienyllithium is manufactured under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, concentration, and solvent specifications. We adhere to cGMP principles where applicable, and our quality systems support compliance with global regulatory standards, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a strong base/organic solvent, highly volatile, and easily oxidized compound, it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Store away from moisture, heat, and ignition sources in a cool, dry, well-ventilated area dedicated to pyrophoric/reactive chemicals.

Specification

Item	Specification
Appearance	Clear solution, colorless to pale yellow
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M to 2.0 M in specified solvent (e.g., THF, Diethyl ether)
Purity (NMR)	≥ 95% (by 1H NMR)
Solvent	As specified (Tetrahydrofuran, Diethyl ether, etc.)
Stability	Stable under inert atmosphere at recommended temperature

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.