Description

Z-Pro-Gly-Oh CAS NO 2766-18-9 is a high-purity, protected tripeptide derivative featuring a C-terminal carboxylic acid. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with proline and glycine residues. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential construction of custom peptide sequences in drug discovery and development.
• Pharmaceutical Research: Used in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and prodrugs targeting various diseases.
• Bioconjugation: Acts as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Biochemical Tool Development: Employed in creating enzyme substrates, inhibitors, or probes for proteomics and biochemical assays.
• Academic & Industrial R&D: Fundamental reagent for exploring peptide structure-activity relationships (SAR) and novel synthetic methodologies.

Basic Information

Product Name	Z-Pro-Gly-Oh
CAS No.	2766-18-9
Molecular Formula	C16H20N2O6
Molecular Weight	336.34 g/mol
Synonyms	Z-Pro-Gly-OH; N-Carbobenzoxy-L-prolylglycine; N-Cbz-L-prolylglycine; Cbz-Pro-Gly-OH; Benzyloxycarbonyl-L-prolylglycine; (S)-2-(((Benzyloxy)carbonyl)amino)-1-((2-oxopyrrolidin-1-yl)methyl)-2-oxoethane-1-carboxylic acid; Z-L-Prolyl-glycine; Nα-Cbz-L-Prolyl-Glycine
EINECS	220-441-5

Quality Control

Our Z-Pro-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-55° to -65° (c=1 in DMF)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.