Description

(S)-1-(2-Phenylacetyl)Pyrrolidine-2-Carboxylic Acid CAS NO 2752-38-7 is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its defined stereochemistry and functional groups, which are critical for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry and process research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Chemistry: Serves as a proline derivative for constructing constrained peptide analogs and peptidomimetics to enhance stability and bioavailability.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• Chemical Biology Research: Employed in the design and synthesis of chemical probes and enzyme inhibitors for biological pathway studies.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(S)-1-(2-Phenylacetyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	2752-38-7
Molecular Formula	C₁₃H₁₅NO₃
Molecular Weight	233.26 g/mol
Synonyms	(S)-1-(Phenylacetyl)pyrrolidine-2-carboxylic acid; L-Proline, 1-(phenylacetyl)-; 1-(2-Phenylacetyl)-(S)-proline; (S)-1-(Phenacyl)pyrrolidine-2-carboxylic acid; (S)-N-(Phenylacetyl)proline; N-Phenylacetyl-L-proline; (2S)-1-(2-Phenylacetyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-1-(2-Phenylacetyl)Pyrrolidine-2-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.