Description

2,3-Difluorofumaric Acid is a fluorinated derivative of fumaric acid, characterized by its strong acidity and unique reactivity profile. This compound serves as a versatile and valuable fluorinated building block in advanced organic synthesis, enabling the introduction of fluorine atoms and difluoromethylene units into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including protease inhibitors and kinase inhibitors, where fluorine substitution can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging fluorine's ability to improve lipophilicity and biological activity.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and other advanced materials requiring specific electronic or surface properties.
• Cross-Coupling Reagent: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions to construct complex, fluorinated organic molecules.
• Biochemical Research: Utilized as a tool compound in mechanistic studies and as a precursor for fluorinated analogs of biological molecules.
• Organic Synthesis Building Block: Serves as a dienophile in Diels-Alder reactions and a Michael acceptor, facilitating the synthesis of diverse fluorinated heterocycles and alicyclic compounds.

Basic Information

Product Name	2,3-Difluorofumaric Acid
CAS No.	2714-32-1
Molecular Formula	C4H2F2O4
Molecular Weight	136.06 g/mol
Synonyms	(E)-2,3-Difluorobut-2-enedioic Acid; trans-2,3-Difluorofumaric Acid; 2,3-Difluoromaleic Acid (isomer); Difluorofumaric Acid; (E)-2,3-Difluoro-2-butenedioic Acid; 2,3-Difluorosuccinic Acid (unsaturated); Fumaric Acid, 2,3-difluoro-
EINECS	Contact for details

Quality Control

Our 2,3-Difluorofumaric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as bases, oxidizing agents, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.