Description

Z-Leu-Gly-Oh is a protected dipeptide derivative featuring a benzyloxycarbonyl (Z) group at the N-terminus and a free carboxylic acid at the C-terminus. This molecular architecture makes it a versatile and crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers for the development of therapeutic peptides, biochemical probes, and complex organic molecules.

Application

• Peptide Synthesis Intermediate: A fundamental building block for the solid-phase and solution-phase synthesis of longer, biologically active peptide sequences.
• Pharmaceutical Research: Used in the R&D of novel peptide-based drugs, hormones, and enzyme inhibitors.
• Bioconjugation: Serves as a spacer or linker molecule in the conjugation of peptides to other biomolecules, polymers, or surfaces.
• Biochemical Tool Development: Employed in creating substrates for protease enzyme studies and diagnostic assays.
• Academic Research: Utilized in university and institutional labs for studying peptide structure, function, and metabolism.
• Custom Synthesis: A key starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides for clients.

Basic Information

Product Name	Z-Leu-Gly-Oh
CAS No.	2706-38-9
Molecular Formula	C16H22N2O5
Molecular Weight	322.36 g/mol
Synonyms	N-Benzyloxycarbonyl-L-leucylglycine; Z-L-Leu-Gly-OH; Cbz-L-Leu-Gly-OH; N-Carbobenzoxy-L-leucylglycine; Benzyl N-[(2S)-1-[(carboxymethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamate; Nα-Cbz-L-leucylglycine; (S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our Z-Leu-Gly-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity, ensuring it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in AcOH)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.