Description

Laudanosine CAS NO 2688-77-9 is a benzylisoquinoline alkaloid, recognized as a significant metabolite of the neuromuscular blocking agent atracurium. This compound is of critical importance in pharmaceutical research and development, particularly for pharmacokinetic studies and safety assessments related to anesthesia. It serves as a key reference standard and intermediate for researchers and manufacturers in the pharmaceutical, analytical chemistry, and life science sectors who require high-purity compounds for method development, quality control, and toxicological evaluation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of laudanosine in drug substances and biological samples.
• Metabolite Studies: Essential for pharmacokinetic and metabolic pathway research of atracurium and related neuromuscular blocking agents.
• Analytical Method Development: Serves as a critical standard in HPLC, LC-MS, and GC-MS methods for assay validation and impurity profiling.
• Toxicological Research: Employed in safety and toxicology studies to understand the effects and clearance of atracurium metabolites.
• Chemical Synthesis: Acts as a valuable intermediate or starting material in the organic synthesis of more complex alkaloids and pharmaceutical compounds.
• Quality Control Laboratories: Used by QC labs in pharmaceutical manufacturing to monitor and control the level of laudanosine in atracurium besylate and similar drug products.

Basic Information

Product Name	Laudanosine
CAS No.	2688-77-9
Molecular Formula	C21H27NO4
Molecular Weight	357.45 g/mol
Synonyms	1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; Laudanosin; N-Methyltetrahydropapaverine; NSC 143491; Atracurium Impurity C; (S)-Laudanosine; Tetrahydropapaverine, N-methyl-
EINECS	220-258-1

Quality Control

Our Laudanosine is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry, to ensure it meets the stringent requirements for use as a reference standard. Certificates of Analysis (COA) with detailed chromatographic data are provided, confirming compliance with in-house specifications tailored for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.