Description

4-Nitrophenylsulfur Pentafluoride is a specialized fluorinated organosulfur compound, serving as a high-value synthetic building block. Its core value lies in its ability to act as a potent electrophilic fluorinating agent and a versatile precursor for introducing the pentafluorosulfanyl (SF5) group into organic molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability and lipophilicity. Its unique reactivity profile also makes it valuable in advanced material science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates containing the pentafluorosulfanyl (SF5) pharmacophore, which can improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, insecticides, and fungicides with the SF5 group for enhanced efficacy and environmental profile.
• Electrophilic Fluorination Reagent: Acts as a source of electrophilic fluorine in organic synthesis for the selective fluorination of complex molecules.
• Material Science Precursor: Employed in the synthesis of advanced materials, including specialty polymers, liquid crystals, and electronic chemicals with unique dielectric properties.
• Chemical Research & Development: A valuable tool in academic and industrial R&D labs for exploring new reactions and creating libraries of SF5-containing compounds for screening.
• Radiochemistry: Potential precursor for the synthesis of fluorine-18 labeled compounds used in Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	4-Nitrophenylsulfur Pentafluoride
CAS No.	2613-27-6
Molecular Formula	C6H4F5NO2S
Molecular Weight	249.16 g/mol
Synonyms	p-Nitrophenylsulfur Pentafluoride; 1-Nitro-4-(pentafluorosulfanyl)benzene; 4-Nitrophenyl SF5; (4-Nitrophenyl)sulfur pentafluoride; Pentafluoro(4-nitrophenyl)sulfurane; SF5-Benzene, 4-nitro-; 4-Nitro-1-(pentafluorosulfanyl)benzene; 4-Nitrophenylsulfur pentafluoride
EINECS	Contact for details

Quality Control

Our 4-Nitrophenylsulfur Pentafluoride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture ingress and decomposition. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.