Description

Z-D-Phe-Onp CAS NO 2578-85-0 is a high-purity, protected amino acid derivative, specifically the p-nitrophenyl ester of N-benzyloxycarbonyl-D-phenylalanine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled, sequential addition of the D-phenylalanine residue. It is essential for researchers and manufacturers developing novel peptides, peptidomimetics, and pharmaceutical intermediates where precise stereochemistry and coupling efficiency are paramount. Its primary utility is found in advanced organic synthesis and the production of specialized bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key activated ester reagent for the efficient incorporation of the D-phenylalanine residue into peptide chains.
• Solution-Phase Peptide Coupling: Used in traditional peptide bond formation reactions where the activated ONp ester offers advantageous reactivity.
• Pharmaceutical Intermediate Manufacturing: Serves as a crucial precursor in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in academic and industrial R&D for constructing model peptides, enzyme substrates, and inhibitors.
• Production of Non-Natural Amino Acid Derivatives: Utilized to create custom amino acid building blocks for drug discovery and material science.
• Synthesis of Chiral Compounds: Acts as a source of chiral D-configuration for the asymmetric synthesis of more complex molecules.

Basic Information

Product Name	Z-D-Phe-Onp
CAS No.	2578-85-0
Molecular Formula	C23H20N2O6
Molecular Weight	420.42 g/mol
Synonyms	N-Carbobenzoxy-D-phenylalanine p-nitrophenyl ester; Z-D-Phenylalanine 4-nitrophenyl ester; (R)-2-(((Benzyloxy)carbonyl)amino)-3-phenylpropanoic acid 4-nitrophenyl ester; D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; Cbz-D-Phe-ONp; Z-D-Phe-ONp; N-Cbz-D-Phenylalanine p-Nitrophenyl Ester; Benzyloxycarbonyl-D-phenylalanine p-nitrophenyl ester
EINECS	219-934-9

Quality Control

Our Z-D-Phe-Onp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding synthetic applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and melting point determination. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.