Description

3-Fluorophenylacetylene is a versatile fluorinated aromatic alkyne building block, essential for advanced organic synthesis. Its unique structure, featuring both a reactive terminal alkyne group and a fluorine-substituted aromatic ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This high-purity compound is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions, click chemistry, and the development of novel electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and pesticides where the fluorine atom and alkyne functionality contribute to biological activity and environmental persistence.
• Material Science & OLED Development: Serves as a building block for conjugated polymers, liquid crystals, and organic light-emitting diode (OLED) materials, where fluorination improves charge transport and device efficiency.
• Cross-Coupling Reactions (Sonogashira, Heck): A fundamental reactant in palladium-catalyzed coupling reactions to form carbon-carbon bonds, enabling the construction of complex molecular architectures.
• Click Chemistry (CuAAC): An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating the rapid and modular assembly of bioconjugates and polymers.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	3-Fluorophenylacetylene
CAS No.	2561-17-3
Molecular Formula	C8H5F
Molecular Weight	120.12 g/mol
Synonyms	3-Fluoroethynylbenzene; 1-Ethynyl-3-fluorobenzene; m-Fluorophenylacetylene; 3-Fluorobenzeneacetylene; (3-Fluorophenyl)ethyne; 3-Fluoro-1-ethynylbenzene; 3-Fluorobenzene, ethynyl-
EINECS	219-900-5

Quality Control

Our 3-Fluorophenylacetylene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, and we support our clients' needs for regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.