Description

Boc-L-Methionine CAS NO 2488-15-5 is a high-purity, N-Boc protected derivative of the essential amino acid L-Methionine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it provides orthogonal protection for the amine group, enabling the controlled construction of complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the automated synthesis of peptide chains in drug discovery and development.
• Pharmaceutical Intermediates: Used in the production of active pharmaceutical ingredients (APIs) for peptide-based therapeutics.
• Biochemical Research: A fundamental reagent for studying protein structure, function, and enzyme-substrate interactions.
• Proteomics & Genomics: Employed in the synthesis of labeled peptides for mass spectrometry and other analytical techniques.
• Antibody-Drug Conjugate (ADC) Development: Serves as a linker component or modified amino acid in the design of targeted cancer therapies.
• Cosmetic Peptides: A raw material for synthesizing bioactive peptides used in advanced skincare formulations.

Basic Information

Product Name	Boc-L-Methionine
CAS No.	2488-15-5
Molecular Formula	C10H19NO4S
Molecular Weight	249.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-methionine; (S)-2-((tert-Butoxycarbonyl)amino)-4-(methylthio)butanoic acid; Boc-Met-OH; BOC-Methionine; N-Boc-L-methionine; N-tert-Butoxycarbonyl-L-methionine; L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyloxycarbonyl-L-methionine
EINECS	219-646-8

Quality Control

Our Boc-L-Methionine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications. The product meets high-purity standards suitable for pharmaceutical research and GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-22.0° to -25.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.