Description

n-tert-Butylformamide (CAS NO 2425-74-3) is a versatile formamide derivative that serves as a critical building block and reagent in advanced organic synthesis. Its unique sterically hindered tert-butyl group adjacent to the formamide functionality makes it a valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from peptide mimetics to the synthesis of novel heterocycles.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the tert-butylamide moiety.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and plant growth regulators.
• Peptidomimetics & Drug Discovery: Employed as a constrained scaffold in medicinal chemistry to mimic peptide bonds and improve metabolic stability of drug candidates.
• Ligand & Catalyst Preparation: Serves as a precursor for nitrogen-containing ligands used in homogeneous catalysis.
• Polymer Chemistry: Acts as a monomer or modifying agent in the synthesis of specialized polyamides and other polymers.
• Organic Synthesis Reagent: Utilized in various reactions, including Vilsmeier-Haack formulations and as a protected form of a primary amine.

Basic Information

Product Name	n-tert-Butylformamide
CAS No.	2425-74-3
Molecular Formula	C5H11NO
Molecular Weight	101.15 g/mol
Synonyms	N-(1,1-Dimethylethyl)formamide; N-(tert-Butyl)formamide; t-Butylformamide; 2-Methyl-2-propylformamide; Formic acid tert-butylamide; tert-Butylcarboxamide; N-Formyl-tert-butylamine
EINECS	219-363-5

Quality Control

Our n-tert-Butylformamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of our global B2B clients. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. The product is hygroscopic (moisture-sensitive); ensure containers are sealed after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.434
Density (20°C)	0.90 - 0.94 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.