Description

n-Cbz-Val-Gly Methyl Ester is a protected dipeptide building block widely used in solid-phase peptide synthesis (SPPS). This compound is valued for its role in constructing peptide backbones with specific stereochemistry and side-chain protection. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for the development of therapeutic peptides and peptidomimetics.

Application

• Pharmaceutical Intermediates: A key building block in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected valylglycine derivative for the sequential assembly of custom peptide sequences.
• Biochemical Research: Employed in academic and industrial R&D for studying peptide structure-activity relationships (SAR).
• Peptidomimetic Development: Serves as a precursor in the design of novel compounds that mimic the biological activity of natural peptides.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse peptide libraries for high-throughput screening.
• Custom Peptide Services: A standard reagent used by CROs and CDMOs for client-specific peptide manufacturing.

Basic Information

Product Name	n-Cbz-Val-Gly Methyl Ester
CAS No.	2421-61-6
Molecular Formula	C17H24N2O5
Molecular Weight	336.38 g/mol
Synonyms	Carbobenzoxy-Valyl-Glycine Methyl Ester; N-Carbobenzyloxy-L-valylglycine Methyl Ester; Z-Val-Gly-OMe; Cbz-Val-Gly-OMe; Nα-Cbz-L-valylglycine Methyl Ester; Benzyl N-[(2S)-1-[(Methoxycarbonyl)methylamino]-3-methyl-1-oxobutan-2-yl]carbamate; (S)-Methyl 2-(2-((((Benzyloxy)carbonyl)amino)-3-methylbutanamido)acetate
EINECS	Contact for details

Quality Control

Our n-Cbz-Val-Gly Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.