Description

Boc-L-Glutamic Acid CAS NO 2419-94-5 is a high-purity, protected amino acid derivative essential for modern peptide synthesis. Its primary value lies in providing a selectively removable tert-butoxycarbonyl (Boc) protecting group for the γ-carboxyl side chain of glutamic acid, enabling precise and complex peptide construction. This compound is critically needed by research institutions and pharmaceutical manufacturers developing therapeutic peptides, diagnostic agents, and novel biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for incorporating glutamic acid residues with protected side chains into peptide sequences.
• Pharmaceutical Intermediates: Serves as a critical raw material in the production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Linker Chemistry: Used to create functionalized peptides for antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Biochemical Research: Essential for studying protein-protein interactions, enzyme mechanisms, and signal transduction pathways using synthetic peptide probes.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Material Science: Used in the synthesis of peptide-based polymers and biomaterials with specific functional properties.

Basic Information

Product Name	Boc-L-Glutamic Acid
CAS No.	2419-94-5
Molecular Formula	C10H17NO6
Molecular Weight	247.25 g/mol
Synonyms	N-tert-Butoxycarbonyl-L-glutamic Acid; (S)-2-((tert-Butoxycarbonyl)amino)pentanedioic Acid; Boc-Glu-OH; BOC-L-Glu; N-Boc-L-glutamic Acid; N-α-Boc-L-glutamic Acid; N-(tert-Butoxycarbonyl)-L-glutamic Acid; L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	219-340-7

Quality Control

Our Boc-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Specific Rotation	-15.0° to -17.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.