Description

n-Trifluoroacetyl-L-Glutamine is a high-purity, specialty amino acid derivative where the amine group of L-glutamine is protected by a trifluoroacetyl moiety. This modification is critical for its primary role as a key synthetic intermediate and protecting group reagent in advanced organic and peptide chemistry. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptide-based therapeutics, prodrugs, and complex bioactive molecules where precise stereochemistry and functional group manipulation are required.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex peptide drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected glutamine derivative in solid-phase and solution-phase peptide synthesis to prevent unwanted side reactions.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescent probes, affinity labels, and other bioconjugates for biochemical research.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the design of glutamine analogs with modified pharmacological properties.
• Biochemical Reagent: Used in enzymatic studies and as a substrate analog in metabolic pathway research.
• Process Development: Utilized in scaling up synthetic routes for GMP (Good Manufacturing Practice) production of therapeutic candidates.

Basic Information

Product Name	n-Trifluoroacetyl-L-Glutamine
CAS No.	2419-34-3
Molecular Formula	C7H9F3N2O4
Molecular Weight	242.15 g/mol
Synonyms	L-Glutamine, N-(trifluoroacetyl)-; Nα-Trifluoroacetyl-L-glutamine; N-TFA-L-glutamine; (S)-2-(Trifluoroacetamido)pentanediamide; TFA-Gln-OH; 2-(Trifluoroacetamido)-4-carbamoylbutanoic acid; N-(Trifluoroacetyl)glutamine; Fmoc-Gln(Trt)-OH precursor
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl-L-Glutamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with key parameters including assay (HPLC), chiral purity, and impurity profiles. Our quality commitment supports applications in research and cGMP-compliant development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.