Description

16β-Fluoro-3-Methoxy-1,3,5(10)-Estratrien-17-One is a high-purity fluorinated steroid derivative, serving as a critical advanced intermediate in pharmaceutical synthesis. Its value lies in providing a precise chemical scaffold for the development of novel therapeutic agents, particularly in the field of endocrinology and oncology. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of steroidal drugs, hormone modulators, and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced fluorinated steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of new chemical entities (NCEs).
• Endocrine Research: Serves as a precursor or analog in the development of hormone receptor modulators and related therapeutic agents.
• Oncological Drug Development: Investigated for its potential utility in creating targeted therapies for hormone-sensitive cancers.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	16β-Fluoro-3-Methoxy-1,3,5(10)-Estratrien-17-One
CAS No.	2383-29-1
Molecular Formula	C19H25FO2
Molecular Weight	304.40 g/mol
Synonyms	16β-Fluoro-3-methoxyestra-1,3,5(10)-trien-17-one; 16β-Fluoro-3-methoxy-1,3,5(10)-estratrien-17-one; 16β-Fluoro-3-methoxyestra-1,3,5(10)-trien-17-one; 16β-Fluoro-3-methoxyestrone; 16-Fluoro-3-methoxyestra-1,3,5(10)-trien-17-one (16β); 2383-29-1; NSC 121773
EINECS	Contact for details

Quality Control

Our 16β-Fluoro-3-Methoxy-1,3,5(10)-Estratrien-17-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.