Description

Ethyl 3,3-Difluorobutyrate is a versatile fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms, which can dramatically alter the physical, chemical, and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop new active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used to construct novel fluorinated herbicides, fungicides, and insecticides, where fluorine atoms improve weatherfastness, uptake, and biological activity.
• Liquid Crystal & Electronic Materials: Serves as a building block for fluorinated liquid crystal compounds and dielectric materials used in displays and advanced electronics.
• Organic Synthesis Reagent: Employed in various carbon-carbon bond-forming reactions, such as Reformatsky-type reactions and nucleophilic additions, to introduce difluorinated butyrate motifs.
• Flavor & Fragrance Chemistry: Potential intermediate for creating unique, stable fluorinated aroma chemicals, though subject to strict regulatory approval for end-use.
• Polymer Modification: Can be used to introduce fluorine-containing side chains into polymers, potentially altering surface properties, solvent resistance, and thermal stability.

Basic Information

Product Name	Ethyl 3,3-Difluorobutyrate
CAS No.	2368-93-6
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	3,3-Difluorobutyric Acid Ethyl Ester; Ethyl 3,3-Difluorobutanoate; Butanoic acid, 3,3-difluoro-, ethyl ester; 3,3-Difluorobutanoic Acid Ethyl Ester; Ethyl β,β-Difluorobutyrate; EFDB; 2368-93-6; NSC 163046
EINECS	Contact for details

Quality Control

Our Ethyl 3,3-Difluorobutyrate is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature: 2-8°C for extended shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.3750 - 1.3850
Density (20°C)	1.10 - 1.20 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.