Description

Ethyl 2,2-Difluorobutanoate is a versatile fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the strategic introduction of difluoromethylene groups, which can dramatically alter the physicochemical and metabolic properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), where the difluoromethylene unit improves metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, leveraging fluorine's ability to enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers and coatings with unique surface properties and chemical resistance.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and dielectric materials.
• Organic Synthesis Building Block: Utilized in various carbon-carbon bond formation reactions, such as Reformatsky-type reactions, to construct complex fluorinated molecules.
• Flavor & Fragrance Industry: Potential use in creating novel, stable fluorinated aroma compounds, though typically at research scale.

Basic Information

Product Name	Ethyl 2,2-Difluorobutanoate
CAS No.	2368-92-5
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	2,2-Difluorobutanoic Acid Ethyl Ester; Ethyl 2,2-Difluorobutyrate; Butanoic Acid, 2,2-Difluoro-, Ethyl Ester; Ethyl α,α-Difluorobutyrate; NSC 523258; EINECS 219-143-7
EINECS	219-143-7

Quality Control

Our Ethyl 2,2-Difluorobutanoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.375 - 1.385
Density (20°C)	1.10 - 1.20 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.