Description

4-Fluoro-2-Butenoic Acid Methyl Ester is a versatile fluorinated building block with significant synthetic utility. This compound matters as a key intermediate for introducing fluorine atoms into complex molecules, a strategy widely used to modulate the biological activity, metabolic stability, and lipophilicity of target compounds. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for developing novel fluorinated polymers with specialized properties like chemical resistance or low surface energy.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and other electronic materials.
• Organic Synthesis & Catalysis: Acts as a Michael acceptor or electrophile in various carbon-carbon and carbon-heteroatom bond-forming reactions under catalysis.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies in organofluorine chemistry.

Basic Information

Product Name	4-Fluoro-2-Butenoic Acid Methyl Ester
CAS No.	2367-25-1
Molecular Formula	C5H7FO2
Molecular Weight	118.10 g/mol
Synonyms	Methyl 4-Fluoro-2-butenoate; (E)-Methyl 4-fluorobut-2-enoate; 4-Fluorocrotonic Acid Methyl Ester; Methyl (E)-4-fluorobut-2-enoate; 2-Butenoic acid, 4-fluoro-, methyl ester; Methyl 4-fluorocrotonate; trans-4-Fluorocrotonic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Butenoic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong bases and fluorides. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Isomer Ratio (GC)	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.