Description

2,2-Difluorobutyric Acid is a versatile fluorinated carboxylic acid building block of significant interest in advanced organic synthesis. Its value lies in the introduction of two fluorine atoms adjacent to the carbonyl group, which can dramatically alter the electronic properties, metabolic stability, and lipophilicity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated analogs of drug candidates, potentially enhancing their bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where fluorine incorporation often improves efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorine into polymer chains, imparting properties like oil/water repellency and chemical resistance.
• Organic Synthesis Building Block: Employed in various reactions, including esterifications and amide couplings, to create complex fluorinated molecules for research.
• Catalyst and Ligand Preparation: Useful in the synthesis of fluorinated ligands for metal catalysis, which can offer unique reactivity and selectivity.

Basic Information

Product Name	2,2-Difluorobutyric Acid
CAS No.	2366-62-3
Molecular Formula	C4H6F2O2
Molecular Weight	124.09 g/mol
Synonyms	2,2-Difluorobutanoic Acid; α,α-Difluorobutyric Acid; Butanoic acid, 2,2-difluoro-; DFBA; 2,2-Difluoro-butanoic acid
EINECS	219-124-6

Quality Control

Our 2,2-Difluorobutyric Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and acidic nature, the container must be kept tightly sealed to exclude moisture and stored separately from bases and reactive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC or HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.