Description

Methyl 2-Fluoropropionate is a versatile fluorinated ester building block with significant utility in advanced organic synthesis. Its primary value lies in introducing the 2-fluoropropionate moiety, a key structural motif for modifying molecular properties such as metabolic stability and lipophilicity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), where the fluorine atom can enhance bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, leveraging the fluorine atom to improve efficacy and environmental profile.
• Liquid Crystal & Electronic Chemicals: Serves as a building block for fluorinated compounds used in liquid crystal displays (LCDs) and dielectric materials.
• Organic Synthesis Reagent: Employed in various fluorination reactions and as a protecting group or ester component in complex multi-step syntheses.
• Polymer Modification: Acts as a monomer or modifier for introducing fluorine into polymer chains, altering surface properties and chemical resistance.
• Flavor & Fragrance Industry: Potential use in the synthesis of fluorinated aroma chemicals, although specific applications require thorough regulatory evaluation.

Basic Information

Product Name	Methyl 2-Fluoropropionate
CAS No.	2366-56-5
Molecular Formula	C4H7FO2
Molecular Weight	106.10 g/mol
Synonyms	2-Fluoropropionic Acid Methyl Ester; Methyl α-Fluoropropionate; Methyl 2-Fluoropropanoate; 2-Fluoropropanoic Acid Methyl Ester; Propanoic acid, 2-fluoro-, methyl ester; Methyl DL-2-fluoropropionate; Methyl (±)-2-fluoropropionate
EINECS	219-124-4

Quality Control

Our Methyl 2-Fluoropropionate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended long-term storage temperature is 2-8°C (refrigerated) to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.05 - 1.10 g/mL
Refractive Index (n20D)	1.365 - 1.375

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.