Description

H-Phe-Pna Hcl is a protected amino acid derivative, specifically the hydrochloride salt of phenylalanine p-nitroanilide. This high-purity building block is essential for advanced peptide synthesis and biochemical research, offering a stable and reactive intermediate. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on protease substrate development and organic synthesis.

Application

• Peptide Synthesis Intermediate: A key protected building block for the solid-phase and solution-phase synthesis of complex peptides and peptide mimetics.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies, particularly for investigating protease (e.g., chymotrypsin, subtilisin) activity and kinetics.
• Pharmaceutical Development: Serves as a critical precursor in the research and development of novel therapeutic agents, including enzyme-targeted drugs.
• Fine Chemical Production: Employed in the custom synthesis of high-value, non-standard amino acid derivatives and chiral compounds for various industrial applications.
• Academic Research: A valuable reagent for university and institutional labs conducting studies in bioorganic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	H-Phe-Pna Hcl
CAS No.	2360-97-6
Molecular Formula	C15H15N3O3 • HCl
Molecular Weight	321.76 g/mol (Free base: 285.30)
Synonyms	L-Phenylalanine p-nitroanilide hydrochloride; N-(4-Nitrophenyl)-L-phenylalaninamide hydrochloride; Phe-pNA•HCl; H-Phe-pNA•HCl; H-Phe-4-NA•HCl; L-Phe-4-nitroanilide HCl; Protease Substrate; Chymotrypsin Substrate
EINECS	Contact for details

Quality Control

Our H-Phe-Pna Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the exacting standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.