Description

3,3,3-Trifluoropropyl 4-Methylbenzenesulfonate is a high-value organofluorine building block and sulfonate ester. This compound is critical for introducing the versatile 3,3,3-trifluoropropyl group into target molecules, enabling the fine-tuning of physical and chemical properties. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and prodrugs, leveraging the metabolic stability and lipophilicity imparted by the trifluoropropyl group.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where the fluorine atoms can enhance biological activity, environmental stability, and uptake.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving performance characteristics.
• Polymer & Surface Modifier: Employed to introduce fluorinated side chains into polymers, granting enhanced oil/water repellency, chemical resistance, and low surface energy for coatings and specialty plastics.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in various metal-catalyzed reactions (e.g., Suzuki, Negishi) to construct complex fluorinated architectures.
• Nucleophilic Substitution Substrate: The sulfonate ester is an excellent leaving group, facilitating nucleophilic attack to form new carbon-heteroatom or carbon-carbon bonds with the trifluoropropyl moiety.

Basic Information

Product Name	3,3,3-Trifluoropropyl 4-Methylbenzenesulfonate
CAS No.	2342-67-8
Molecular Formula	C10H11F3O3S
Molecular Weight	268.25 g/mol
Synonyms	3,3,3-Trifluoropropyl p-Toluenesulfonate; 1,1,1-Trifluoro-3-[(4-methylphenyl)sulfonyloxy]propane; p-Toluenesulfonic Acid 3,3,3-Trifluoropropyl Ester; 3,3,3-Trifluoropropyl Tosylate; 3,3,3-Trifluoropropanol p-Toluenesulfonate Ester; 4-Methylbenzenesulfonic Acid 3,3,3-Trifluoropropyl Ester; 3,3,3-Trifluoropropyl-1-p-toluenesulfonate; Tosic Acid 3,3,3-Trifluoropropyl Ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our commitment to quality supports applications in cGMP environments and research requiring high-purity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.