Description

2-(Difluoromethoxy)Quinoline is a specialized fluorinated quinoline derivative, a high-value building block in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoromethoxy group, which is critical for modulating the physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for synthesizing functionalized organic materials, including ligands for catalysis and components for organic electronics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	2-(Difluoromethoxy)Quinoline
CAS No.	2341-27-7
Molecular Formula	C₁₀H₇F₂NO
Molecular Weight	195.17 g/mol
Synonyms	Quinoline, 2-(difluoromethoxy)-; 2-Quinolyl Difluoromethyl Ether; 2-(Difluoromethoxy)quinoline; 2341-27-7; 2-Quinolyloxydifluoromethane; Difluoromethoxyquinoline; 2-Difluoromethoxyquinoline
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Quinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade) ≥98.0% / ≥99.0% (Higher grades available)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.