Description

4-Fluoro-3-Methylanisole is a versatile fluorinated aromatic ether, serving as a critical building block in advanced organic synthesis. This compound is valued for its ability to introduce both fluorine and methoxy substituents into molecular frameworks, enabling fine-tuning of electronic properties and lipophilicity. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atom improves biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a starting material for synthesizing fluorinated components used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, functionalized aromatic compounds.
• Dye & Pigment Intermediate: Utilized in the production of specialized dyes and pigments where fluorine substitution alters color fastness and spectral properties.

Basic Information

Product Name	4-Fluoro-3-Methylanisole
CAS No.	2338-54-7
Molecular Formula	C8H9FO
Molecular Weight	140.16 g/mol
Synonyms	1-Fluoro-2-Methoxy-4-Methylbenzene; 3-Methyl-4-Fluoroanisole; 4-Fluoro-3-Methyl-1-Methoxybenzene; 2-Methoxy-4-Methylfluorobenzene; 4-Fluoro-m-Cresol Methyl Ether; 4-Fluoro-3-Methylphenyl Methyl Ether; p-Fluoro-m-Methylanisole
EINECS	219-058-5

Quality Control

Our 4-Fluoro-3-Methylanisole is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.10 g/cm³
Refractive Index (n20D)	~1.495 - 1.505

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.