Description

3-Bromo-4-Hydroxybenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing cyano group and a bromine substituent on a phenolic ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection. Its reactivity allows for selective functionalization, enabling the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for synthesizing specialized aromatic cores used in electronic display and lighting technologies.
• Polymer Modification: Employed to introduce functional groups into polymer backbones to alter material properties like thermal stability or solubility.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to form new carbon-carbon and carbon-heteroatom bonds.
• Chemical Research & Development: A valuable reagent in academic and industrial labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	3-Bromo-4-Hydroxybenzonitrile
CAS No.	2315-86-8
Molecular Formula	C7H4BrNO
Molecular Weight	198.02 g/mol
Synonyms	4-Cyano-2-bromophenol; 2-Bromo-4-cyanophenol; 4-Hydroxy-3-bromobenzonitrile; 3-Bromo-4-hydroxybenzenecarbonitrile; Benzonitrile, 3-bromo-4-hydroxy-; 2-Bromo-4-hydroxybenzonitrile; 3-Bromo-4-cyanophenol
EINECS	219-028-5

Quality Control

Our 3-Bromo-4-Hydroxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.