Description

Z-Arg(No2)-Oh is a protected derivative of the amino acid L-arginine, featuring a nitro group (NO2) on the guanidine side chain. This specific chemical modification is critical for peptide synthesis, where it prevents unwanted side reactions and allows for selective deprotection. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of arginine into peptide chains.
• Pharmaceutical Research: Used in the development and production of peptide drugs targeting cardiovascular, metabolic, and oncological diseases.
• Bioconjugation: Serves as a functional handle for attaching peptides to other molecules, such as dyes, polymers, or drug carriers.
• Enzyme Substrate Analogues: Employed in biochemical studies to investigate enzyme mechanisms, particularly those involving trypsin-like proteases.
• Antigen Preparation: Useful for synthesizing specific peptide sequences for antibody production and immunological assays.
• Chemical Biology Probes: Building block for creating tools to study nitric oxide (NO) signaling pathways and protein-protein interactions.

Basic Information

Product Name	Z-Arg(No2)-Oh
CAS No.	2304-98-5
Molecular Formula	C₁₄H₁₉N₅O₆
Molecular Weight	353.33 g/mol
Synonyms	Nα-Carbobenzoxy-Nω-nitro-L-arginine; Z-Nω-Nitro-L-arginine; Nα-Z-Nω-Nitro-L-arginine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(nitroamino)pentanoic acid; Z-Arg(NO2)-OH; CBZ-Nitroarginine; Fmoc-Arg(NO2)-OH (Note: This is the Fmoc-protected variant); Nω-Nitro-Nα-[(phenylmethoxy)carbonyl]-L-arginine
EINECS	Contact for details

Quality Control

Our Z-Arg(No2)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	+15.0° to +18.0° (c=1 in AcOH)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.