Description

n-Benzyloxycarbonyl-L-Asparagine is a protected derivative of the amino acid L-asparagine, widely used as a key chiral building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial, protected asparagine residue for the sequential assembly of peptide chains, preventing unwanted side reactions.
• Solution-Phase Peptide Chemistry: Used in classical peptide coupling methodologies for the production of custom peptides and peptide conjugates.
• Pharmaceutical Intermediate: Acts as a key raw material in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the site-specific modification of proteins or other biomolecules by providing a reactive handle for further chemical linkage.
• Biochemical Research: Employed in studies of enzyme substrates, receptor ligands, and as a standard in analytical method development for amino acid analysis.
• Combinatorial Chemistry: Used in libraries for drug discovery to explore structure-activity relationships of peptide analogs.

Basic Information

Product Name	n-Benzyloxycarbonyl-L-Asparagine
CAS No.	2304-96-3
Molecular Formula	C12H14N2O5
Molecular Weight	266.25 g/mol
Synonyms	Z-L-Asparagine; Z-Asn-OH; Nα-Cbz-L-asparagine; N-Carbobenzoxy-L-asparagine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-4-amino-4-oxobutanoic acid; L-Asparagine, N-benzyloxycarbonyl-; Benzyloxycarbonylasparagine; CBZ-L-Asn
EINECS	218-980-4

Quality Control

Our n-Benzyloxycarbonyl-L-Asparagine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% L-Isomer
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.