Description

n-Desmethyltrimipramine,1.0Mg/Mlinmethanol CAS NO 2293-21-2 is a certified reference material (CRM) presented as a precise 1.0 mg/mL solution in methanol, designed for analytical and research applications. This high-purity standard is critical for ensuring accurate quantification, method validation, and quality control in analytical laboratories. It is primarily utilized by pharmaceutical researchers, forensic toxicologists, and analytical chemists for metabolite studies, pharmacokinetic research, and compliance testing.

Application

• Pharmaceutical Research & Development: Used as a primary analytical standard for the quantification of trimipramine and its metabolites in pharmacokinetic and metabolic stability studies.
• Forensic Toxicology & Clinical Analysis: Serves as a critical reference for the accurate identification and measurement of desmethyltrimipramine in biological matrices (e.g., blood, plasma, urine) for drug monitoring and forensic investigations.
• Analytical Method Development & Validation: Essential for developing, calibrating, and validating high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and gas chromatography (GC) methods.
• Quality Control & Assurance (QC/QA): Employed in pharmaceutical manufacturing and testing laboratories to verify the purity of active pharmaceutical ingredients (APIs) and to ensure batch-to-batch consistency.
• Reference Standard for Regulatory Compliance: Supports compliance with Good Laboratory Practice (GLP) and other regulatory requirements by providing a traceable and certified standard for analytical procedures.

Basic Information

Product Name	n-Desmethyltrimipramine,1.0Mg/Mlinmethanol
CAS No.	2293-21-2
Molecular Formula	C19H24N2
Molecular Weight	280.41 g/mol
Synonyms	Desmethyltrimipramine; Nortrimipramine; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenzo[b,f]azepine; 5-(3-Methylaminopropyl)-10,11-dihydro-5H-dibenzazepine; Trimipramine Impurity B; Trimipramine Metabolite; N-Desmethyltrimipramine; NSC 113939
EINECS	Contact for details

Quality Control

This certified reference material is produced under strict quality-controlled conditions to ensure identity, purity, and concentration accuracy. Each batch is characterized using orthogonal analytical techniques, including NMR, mass spectrometry, and chromatographic methods. A comprehensive Certificate of Analysis (COA) is supplied with each unit, providing batch-specific data on assay, solvent content, and verification of the certified value. Our quality system is designed to support GLP and research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated). Due to the highly volatile nature of the methanol solvent, ensure containers are securely sealed and stored in a well-ventilated area. For long-term stability, storage at -20°C is recommended.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Concentration	1.0 mg/mL in Methanol
Certified Value Purity	≥ 98.0% (by HPLC)
Identification (IR / MS)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% of stated concentration
Solvent Verification (GC)	Methanol confirmed
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.