Description

3-Acetylamino-5-(Ethylcarbamoyl)-2,4,6-Triiodobenzoic Acid is a high-purity, tri-iodinated benzoic acid derivative serving as a critical intermediate in advanced pharmaceutical synthesis. Its primary value lies in its role as a key building block for the production of iodinated X-ray contrast media, which are essential for diagnostic imaging procedures. This compound is specifically required by fine chemical manufacturers and pharmaceutical R&D facilities developing next-generation non-ionic, low-osmolar contrast agents to enhance patient safety and diagnostic clarity.

Application

• Pharmaceutical Intermediate: Primary use as a precursor in the synthesis of iodinated X-ray contrast agents like iopamidol, iohexol, and ioversol.
• Diagnostic Imaging Agent Synthesis: Key raw material for manufacturing non-ionic, low-osmolar contrast media used in computed tomography (CT), angiography, and urography.
• Research & Development: Utilized in academic and industrial labs for developing novel contrast agents with improved safety profiles and imaging efficacy.
• Fine Chemical Production: Serves as a specialized intermediate for other iodinated aromatic compounds in advanced organic synthesis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) producing active pharmaceutical ingredients (APIs) for global markets.

Basic Information

Product Name	3-Acetylamino-5-(Ethylcarbamoyl)-2,4,6-Triiodobenzoic Acid
CAS No.	2281-07-4
Molecular Formula	C12H10I3N2O4
Molecular Weight	635.93 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-ethylisophthalamic acid; 2,4,6-Triiodo-3-acetamido-5-(N-ethylcarbamoyl)benzoic acid; AEITB; Iopamidol Intermediate; Iohexol Intermediate; Ioversol Intermediate; Triiodinated Benzoic Acid Derivative; N-Ethyl-2,4,6-triiodo-5-(acetylamino)isophthalamic Acid
EINECS	Contact for details

Quality Control

Our 3-Acetylamino-5-(Ethylcarbamoyl)-2,4,6-Triiodobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and heavy metal screening, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) are provided with each shipment, detailing all specification results. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep the container sealed under an inert gas (e.g., nitrogen or argon) to minimize oxidation and moisture uptake. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5%
Individual Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Iodine Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.