Description

5-Amino-2,4,6-Triiodo-n-Methylisophthalamic Acid is a specialized iodinated organic compound primarily utilized as a key intermediate in the synthesis of X-ray contrast media. This high-purity building block is critical for ensuring the safety, efficacy, and consistent performance of final pharmaceutical formulations. It is essential for manufacturers and R&D laboratories in the pharmaceutical and diagnostic imaging sectors who require reliable, high-quality raw materials for advanced medical applications.

Application

• Primary Intermediate for X-ray Contrast Agents: A crucial building block in the synthesis of non-ionic, low-osmolar contrast media like iopamidol and iohexol derivatives.
• Pharmaceutical Research & Development: Used in the discovery and development of new iodinated diagnostic compounds for enhanced imaging clarity and patient safety.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core precursor in multi-step synthetic routes for final contrast agent APIs.
• Diagnostic Imaging Reagent Manufacturing: Integral to the production chain of reagents used in computed tomography (CT), angiography, and urography.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Specialty Fine Chemical Synthesis: Employed in organic synthesis for creating complex molecules containing triiodinated aromatic systems.

Basic Information

Product Name	5-Amino-2,4,6-Triiodo-n-Methylisophthalamic Acid
CAS No.	2280-89-9
Molecular Formula	C9H7I3N2O3
Molecular Weight	587.87 g/mol
Synonyms	5-Amino-N-methyl-2,4,6-triiodoisophthalamic acid; N-Methyl-5-amino-2,4,6-triiodoisophthalamic acid; 2,4,6-Triiodo-5-amino-N-methylisophthalamic acid; 5-Amino-2,4,6-triiodo-N-methyl-1,3-benzenedicarboxamide; ATMA (common abbreviation); Intermediate for Iopamidol; Iodinated isophthalamic acid derivative; Contrast media intermediate
EINECS	Contact for details

Quality Control

Our production of 5-Amino-2,4,6-Triiodo-n-Methylisophthalamic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. The material is manufactured and controlled to meet the exacting standards required for advanced intermediate use. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.