Description

(S)-(+)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid CAS NO 2280-27-5 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry at the chiral center. This compound serves as a critical chiral building block and pharmacophore in advanced organic synthesis, enabling the development of molecules with targeted biological activity. It is essential for research and production in the pharmaceutical and biotechnology sectors, particularly for creating peptide-based therapeutics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a unique, sterically hindered hydroxy amino acid residue, modifying peptide conformation and stability.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway research due to its structural similarity to natural amino acids.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for asymmetric synthesis.
• Nutraceutical Development: Investigated for potential use in specialized dietary supplements and health products targeting specific metabolic functions.
• Agrochemical Synthesis: A potential intermediate for creating chiral herbicides or plant growth regulators with improved selectivity and environmental profile.

Basic Information

Product Name	(S)-(+)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid
CAS No.	2280-27-5
Molecular Formula	C5H11NO3
Molecular Weight	133.15 g/mol
Synonyms	(S)-2-Amino-3-hydroxy-3-methylbutanoic acid; (S)-3-Hydroxyvaline; L-3-Hydroxyvaline; (2S)-2-Amino-3-hydroxy-3-methylbutanoic acid; Hmb; (S)-3-Hydroxy-3-methylbutyrine; 3-Hydroxy-L-valine; 2280-27-5
EINECS	Contact for details

Quality Control

Our (S)-(+)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess, ensuring compliance with research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.