Description

2-Chloro-4-Fluoroanisole is a versatile halogenated anisole derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for creating complex molecules with tailored properties. This compound is particularly valuable for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to synthesize active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and chlorine atoms enhance biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials.
• Functional Dye Intermediate: Employed in the manufacture of specialized dyes and pigments, where its halogen atoms influence color and fastness properties.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl and complex aromatic structures.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and developing novel fluorinated compounds in academic and industrial R&D labs.

Basic Information

Product Name	2-Chloro-4-Fluoroanisole
CAS No.	2267-25-6
Molecular Formula	C7H6ClFO
Molecular Weight	160.57 g/mol
Synonyms	1-Chloro-2-fluoro-4-methoxybenzene; 2-Chloro-4-fluoro-1-methoxybenzene; 4-Fluoro-2-chloroanisole; 2-Chloro-4-fluorophenyl methyl ether; Anisole, 2-chloro-4-fluoro-; Benzene, 1-chloro-2-fluoro-4-methoxy-; 4-Methoxy-3-chlorofluorobenzene; 2-Fluoro-4-methoxychlorobenzene
EINECS	218-872-8

Quality Control

Our 2-Chloro-4-Fluoroanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C (59°F and 77°F).

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.28 g/cm³
Boiling Point	~205-207 °C
Refractive Index (n20D)	~1.515 - 1.520

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.