Description

Ethyl 2,2-Difluoroacetoacetate is a versatile fluorinated β-ketoester building block, essential for introducing the difluoroacetate moiety into complex molecular architectures. Its high reactivity and unique fluorine substitution pattern make it a critical intermediate for synthesizing compounds with enhanced biological activity and metabolic stability. This product is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated heterocycles, active pharmaceutical ingredients (APIs), and prodrugs, leveraging fluorine's effects on bioavailability and lipophilicity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethyl group can improve efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and coatings with specific chemical resistance or surface properties.
• Fluorine Chemistry Research: An essential reagent in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated compounds for various applications.
• Ligand and Catalyst Development: Utilized in the preparation of fluorinated ligands for metal-organic frameworks (MOFs) or asymmetric catalysis.

Basic Information

Product Name	Ethyl 2,2-Difluoroacetoacetate
CAS No.	2266-48-0
Molecular Formula	C6H8F2O3
Molecular Weight	166.12 g/mol
Synonyms	Ethyl 2,2-Difluoro-3-oxobutanoate; 2,2-Difluoroacetoacetic Acid Ethyl Ester; Ethyl Difluoroacetoacetate; 3-Oxobutanoic Acid, 2,2-Difluoro-, Ethyl Ester; Ethyl 4,4-Difluoroacetoacetate; DFAAE; EDFAA
EINECS	218-873-5

Quality Control

Every batch of Ethyl 2,2-Difluoroacetoacetate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure product integrity and traceability. Our standard quality commitment includes HPLC purity ≥98.0% (typical) and rigorous control of key impurities. A detailed Certificate of Analysis (COA) with batch-specific data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flames. Ensure containers are kept tightly sealed when not in use to prevent evaporation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.