Description

3-(Trifluoromethoxy)Bromobenzene is a versatile fluorinated aromatic building block, specifically a bromobenzene derivative substituted with a trifluoromethoxy group at the meta position. This compound is valued for its unique combination of a reactive bromine handle and the electron-withdrawing, lipophilic trifluoromethoxy moiety, which imparts enhanced metabolic stability and bioavailability to target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for introducing the trifluoromethoxy pharmacophore to enhance drug-like properties.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the CF3O- group improves efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine atom is highly reactive in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) for constructing complex biaryl systems.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and metal-halogen exchange reactions to create a wide array of functionalized aromatic compounds.
• Material Science Research: Used in the development of novel polymers and coatings with specific chemical resistance and surface properties.

Basic Information

Product Name	3-(Trifluoromethoxy)Bromobenzene
CAS No.	2252-44-0
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	1-Bromo-3-(trifluoromethoxy)benzene; m-(Trifluoromethoxy)bromobenzene; 3-Bromophenyl trifluoromethyl ether; (3-Bromophenyl) trifluoromethyl ether; 3-Bromo-α,α,α-trifluoroanisole; 3-Trifluoromethoxybromobenzene; 3-Bromo-1-(trifluoromethoxy)benzene; Benzene, 1-bromo-3-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Bromobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.65 g/cm³
Boiling Point	~185-190 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.