Description

(Alpha,α-Difluoro)Phenylacetic Acid Ethyl Ester is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound matters because its difluoromethylene group (-CF2-) adjacent to the aromatic ring and ester functionality provides unique electronic and steric properties, enabling the development of novel molecules with enhanced metabolic stability and bioavailability. It is primarily needed by R&D and production chemists in the pharmaceutical and agrochemical industries for applications such as the synthesis of protease inhibitors, active pharmaceutical ingredients (APIs), and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly protease inhibitors and other enzyme-targeted therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides, where the difluoro group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and advanced materials requiring fluorinated aromatic components.
• Organic Synthesis Reagent: A versatile reagent in medicinal chemistry for introducing the difluorophenylacetic acid moiety into target molecules via ester hydrolysis or transesterification.
• Fluorine Chemistry Research: Valuable compound for academic and industrial research exploring the effects of gem-difluorination on chemical reactivity and physical properties.

Basic Information

Product Name	(Alpha,α-Difluoro)Phenylacetic Acid Ethyl Ester
CAS No.	2248-46-6
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-phenylethanoate; Ethyl 2,2-Difluoro-2-phenylacetate; 2,2-Difluoro-2-phenylacetic Acid Ethyl Ester; α,α-Difluorophenylacetic Acid Ethyl Ester; Ethyl α,α-Difluorophenylacetate; Phenylacetic Acid, 2,2-Difluoro-, Ethyl Ester; Ethyl (Difluorophenyl)acetate; EDFPA
EINECS	Contact for details

Quality Control

Our (Alpha,α-Difluoro)Phenylacetic Acid Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.