Description

D(-)Penicillamine Hydrochloride is the hydrochloride salt of the D-enantiomer of penicillamine, a sulfur-containing amino acid derived from the hydrolysis of penicillin. This specific chiral form is critical for applications where stereochemical purity directly impacts biological activity and therapeutic efficacy. It serves as a key chiral intermediate and building block in pharmaceutical research and development, particularly for the synthesis of active pharmaceutical ingredients (APIs) and in biochemical studies.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of specific APIs and therapeutic agents.
• Biochemical Research: Used in studies involving chelation, enzyme inhibition, and as a modulator in metabolic pathways.
• Reference Standard: Serves as a high-purity standard for analytical methods, quality control, and regulatory compliance in pharmaceutical laboratories.
• Asymmetric Synthesis: Employed as a chiral ligand or auxiliary in stereoselective chemical synthesis.
• Veterinary Pharmaceuticals: Potential use in the development of treatments for metal toxicity in animals.

Basic Information

Product Name	D(-)Penicillamine Hydrochloride
CAS No.	2219-30-9
Molecular Formula	C5H11NO2S • HCl
Molecular Weight	185.67 g/mol
Synonyms	D-Penicillamine Hydrochloride; (R)-2-Amino-3-mercapto-3-methylbutanoic acid hydrochloride; (R)-3,3-Dimethyl-D-cysteine hydrochloride; D-3-Mercaptovaline hydrochloride; D-β,β-Dimethylcysteine hydrochloride; D-β-Mercaptovaline hydrochloride; D(-)-Penicillamine HCl
EINECS	218-745-8

Quality Control

Our D(-)Penicillamine Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric purity, and impurity profiles. Specifications can be aligned with research-grade or pharmaceutical intermediate requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept tightly sealed after use to minimize exposure to atmospheric moisture. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	-60.0° to -64.0° (c=1 in 1N HCl)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.