Description

4,4,4-Trifluoro-2-Methylbutyronitrile is a versatile fluorinated nitrile building block, essential for introducing the trifluoromethyl group into complex molecular architectures. Its value lies in enabling the synthesis of high-value, biologically active compounds with enhanced metabolic stability and lipophilicity. This intermediate is critically needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel agrochemicals, pharmaceuticals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl moiety to modulate bioavailability and potency.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group contributes to efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its impact on electronic properties.
• Fluorinated Polymer Modifiers: Employed to introduce fluorine into polymer chains, enhancing chemical resistance, thermal stability, and surface properties of specialty plastics and coatings.
• Organic Synthesis Reagent: A versatile reagent in nucleophilic addition and cyclization reactions for constructing complex heterocycles and aliphatic chains in research chemistry.

Basic Information

Product Name	4,4,4-Trifluoro-2-Methylbutyronitrile
CAS No.	2214-85-9
Molecular Formula	C5H6F3N
Molecular Weight	137.10 g/mol
Synonyms	2-Methyl-4,4,4-trifluorobutyronitrile; 4,4,4-Trifluoro-2-methylbutanenitrile; 3,3,3-Trifluoroisovaleronitrile; Butyronitrile, 4,4,4-trifluoro-2-methyl-; (RS)-4,4,4-Trifluoro-2-methylbutyronitrile; α-Methyl-β,β,β-trifluoropropionitrile; TFMBN
EINECS	218-690-9

Quality Control

Our 4,4,4-Trifluoro-2-Methylbutyronitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.