Description

4-Fluoroisobenzofuran-1(3H)-one is a fluorinated heterocyclic compound featuring a fused isobenzofuranone scaffold with a fluorine substituent at the 4-position. It serves as a high-value building block in medicinal chemistry and advanced materials synthesis, valued for its enhanced metabolic stability and tunable electronic properties imparted by the fluorine atom. This compound is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and specialty polymer developers requiring structurally precise fluorinated intermediates. The 4-Fluoroisobenzofuran-1(3H)-One CAS NO 2211-81-6 is supplied under strict quality controls to ensure batch-to-batch consistency and research-grade reliability.

Application

• Key intermediate in the synthesis of fluorinated pharmaceutical candidates, particularly for CNS and oncology targets
• Building block for fluorinated liquid crystals used in high-performance display technologies
• Monomer or co-monomer in the development of fluorinated polyarylates and polyimides with improved thermal stability and dielectric properties
• Reagent in transition-metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex fluorinated biaryl architectures
• Substrate in photochemical and electrochemical studies investigating fluorine-induced electronic modulation in fused furanones
• Probe molecule in structure–activity relationship (SAR) studies evaluating the impact of aromatic fluorination on target binding affinity

Basic Information

Product Name	4-Fluoroisobenzofuran-1(3H)-one
CAS No.	2211-81-6
Molecular Formula	C8H5FO2
Molecular Weight	152.12 g/mol
Synonyms	4-Fluoro-1(3H)-isobenzofuranone; 4-Fluoro-3H-isobenzofuran-1-one; 4-Fluoro-1-oxo-1,3-dihydroisobenzofuran; 4-Fluoroisobenzofuranone; 4-Fluoro-1-oxoisoindoline; NSC 127921; UNII-7JQ0Z6Y8VX; 4-Fluoro-1H-isobenzofuran-1-one (tautomer)
EINECS	218-634-2

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of 4-Fluoroisobenzofuran-1(3H)-one are tested for identity (IR, 1H NMR), assay (HPLC), residual solvents (GC), heavy metals (USP <231>), and related substances. We adhere to ISO 9001-certified manufacturing practices and support regulatory submissions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Keep away from strong oxidizing agents and incompatible materials such as strong alkalis or fluoride sources. Due to potential sensitivity, minimize exposure to ambient moisture and air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (1H NMR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Melting Point	124–128°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.