Description

2-Bromo-2,2-Difluoroacetamide is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine atoms on the same carbon, makes it a valuable reagent for introducing difluoroacetamide motifs into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly those requiring difluoromethyl or gem-difluoro functional groups to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a starting material for synthesizing specialized fluorinated polymers, coatings, and liquid crystals with unique thermal and chemical resistance properties.
• Cross-Coupling Reactions: The bromine atom acts as a handle for various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi), enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry Research: An essential reagent in academic and industrial laboratories focused on exploring new methodologies in organofluorine chemistry.
• Peptide Mimetics: Incorporated into peptide analogs to create hydrolytically stable amide bond isosteres, useful in medicinal chemistry.

Basic Information

Product Name	2-Bromo-2,2-Difluoroacetamide
CAS No.	2169-67-7
Molecular Formula	C2H2BrF2NO
Molecular Weight	173.95 g/mol
Synonyms	2,2-Difluoro-2-bromoacetamide; α-Bromo-α,α-difluoroacetamide; Bromodifluoroacetamide; Difluorobromoacetamide; Acetamide, 2-bromo-2,2-difluoro-; NSC 401119; 2-Bromo-2,2-difluoroethanamide
EINECS	218-513-8

Quality Control

Our 2-Bromo-2,2-Difluoroacetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.