Description

Ethyl Diatrizoate is a specialized iodinated organic compound primarily used as a key intermediate in the synthesis of X-ray contrast media. This high-purity compound is critical for ensuring the safety and efficacy of final diagnostic formulations. It is essential for pharmaceutical manufacturers and advanced research facilities developing non-ionic, low-osmolar contrast agents for enhanced patient safety in radiographic procedures.

Application

• Pharmaceutical Intermediate: Primary use as a building block in the synthesis of iodinated X-ray contrast agents like Iopamidol and Iohexol.
• Diagnostic Imaging Research: Used in R&D for developing new generations of non-ionic, low-osmolar contrast media with improved safety profiles.
• Contrast Agent Formulation: Serves as a precursor in the controlled production of contrast media for computed tomography (CT), angiography, and urography.
• Chemical Synthesis: Employed in organic synthesis for introducing the triiodobenzene moiety into complex molecules.
• Quality Control Reference: Acts as a reference standard in analytical laboratories for method development and impurity profiling of final contrast agents.

Basic Information

Product Name	Ethyl Diatrizoate
CAS No.	2168-75-4
Molecular Formula	C11H9I3N2O4
Molecular Weight	613.91 g/mol
Synonyms	3,5-Diacetamido-2,4,6-triiodobenzoic Acid Ethyl Ester; Ethyl 3,5-Bis(acetylamino)-2,4,6-triiodobenzoate; Diatrizoic Acid Ethyl Ester; Ethyl 2,4,6-Triiodo-3,5-diacetamidobenzoate; NSC 106962; WIN 31138; Ethylester kyseliny diatrizove [Czech]
EINECS	218-514-8

Quality Control

Our Ethyl Diatrizoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for pharmaceutical intermediate use. Certificates of Analysis (COA) are provided with each shipment, detailing all test results against established release criteria.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.