Description

H-Dab(Z)-Oh is a protected derivative of the non-proteinogenic amino acid 2,4-diaminobutyric acid (Dab), featuring a benzyloxycarbonyl (Z) protecting group on one of its amino functionalities. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel therapeutic agents and conducting advanced biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the Dab residue with orthogonal protection.
• Bioconjugation: Acts as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Employed in the study of enzyme inhibitors, receptor ligands, and as a tool compound in proteomics.
• Material Science: Can be utilized in the synthesis of specialized polymers and dendrimers with tailored properties.

Basic Information

Product Name	H-Dab(Z)-Oh
CAS No.	2130-77-0
Molecular Formula	C₁₂H₁₆N₂O₄
Molecular Weight	252.27 g/mol
Synonyms	N2-[(Benzyloxy)carbonyl]-2,4-diaminobutanoic acid; (S)-2-Amino-4-{[(benzyloxy)carbonyl]amino}butanoic acid; H-Dab(Z)-OH; Z-Dab-OH; Nα-Z-L-2,4-diaminobutyric acid; (S)-4-{[(Benzyloxy)carbonyl]amino}-2-aminobutanoic acid; L-2,4-Diaminobutyric acid N2-benzyloxycarbonyl derivative; N2-Cbz-L-2,4-diaminobutyric acid
EINECS	218-365-5

Quality Control

Our H-Dab(Z)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.