Description

H-Lys(Tos)-Oh is a protected derivative of the essential amino acid L-lysine, featuring a tosyl (p-toluenesulfonyl) group on the side-chain ε-amino group. This specific protection is critical for enabling selective peptide bond formation in complex solid-phase peptide synthesis (SPPS) and solution-phase methodologies, preventing unwanted side reactions. It is an indispensable building block for research and production in pharmaceutical development, particularly for creating therapeutic peptides, hormones, and diagnostic agents where precise sequence control is paramount.

Application

• Peptide Synthesis Intermediate: A key protected amino acid for the controlled, stepwise assembly of peptide chains in both research and GMP manufacturing.
• Pharmaceutical Active Pharmaceutical Ingredient (API) Development: Used in the research and scale-up synthesis of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation & Labeling: Serves as a precursor for introducing functional handles or labels onto lysine residues within peptides or proteins.
• Biochemical Research: Employed in academic and industrial laboratories to study protein-protein interactions, enzyme substrates, and receptor ligands.
• Combinatorial Chemistry Libraries: Used as a building block to create diverse arrays of compounds for high-throughput screening in drug discovery.
• Cosmeceutical Peptides: A raw material in the synthesis of bioactive peptides for advanced skincare and anti-aging formulations.

Basic Information

Product Name	H-Lys(Tos)-Oh
CAS No.	2130-76-9
Molecular Formula	C14H22N2O4S
Molecular Weight	314.40 g/mol
Synonyms	Nε-Tosyl-L-lysine; L-Lysine, N6-(p-toluenesulfonyl)-; N6-Tosyl-L-lysine; (S)-2-Amino-6-((4-methylphenyl)sulfonamido)hexanoic acid; H-Lys(Tos)-OH; Tosyl-L-lysine; Fmoc-Lys(Tos)-OH precursor; Boc-Lys(Tos)-OH precursor
EINECS	218-365-5

Quality Control

Our H-Lys(Tos)-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and related substances are provided and traceable to each production lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	+10.0° to +12.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% L-isomer
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.