Description

2-(Trifluoromethoxy)Fluorobenzene is a versatile fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its unique combination of a trifluoromethoxy group and a fluorine atom, which imparts enhanced lipophilicity, metabolic stability, and electronic properties to target molecules. It is primarily needed by pharmaceutical, agrochemical, and material science researchers for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for introducing fluorine motifs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorinated structure can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, value-added fluorinated compounds.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter physical properties such as chemical resistance, thermal stability, and surface characteristics.

Basic Information

Product Name	2-(Trifluoromethoxy)Fluorobenzene
CAS No.	2106-18-5
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	1-Fluoro-2-(trifluoromethoxy)benzene; o-(Trifluoromethoxy)fluorobenzene; 2-Fluorophenyl trifluoromethyl ether; Fluorobenzene, 2-(trifluoromethoxy)-; Benzene, 1-fluoro-2-(trifluoromethoxy)-; α,α,α-Trifluoro-2-fluoroanisole
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.