Description

7-Hydroxychlorpromazine is a key metabolite and reference standard of the antipsychotic drug chlorpromazine. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical methods. It serves as a critical tool for scientists and quality control professionals in the pharmaceutical and life sciences industries who require high-purity reference materials for method validation and impurity profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the identification and quantification of chlorpromazine and its metabolites in drug substances and products.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, bioavailability, and clearance of chlorpromazine.
• Analytical Method Development: Used to develop, validate, and calibrate high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and other analytical techniques.
• Impurity Profiling: Acts as a known impurity standard to monitor and control the quality of chlorpromazine active pharmaceutical ingredients (APIs) according to ICH guidelines.
• Clinical Toxicology: Employed in forensic and clinical laboratories as a calibrant for the accurate detection of chlorpromazine and its metabolites in biological samples.
• Pharmacological Studies: Utilized in research to understand the activity and potential side effects of chlorpromazine metabolites.

Basic Information

Item	Detail
Product Name	7-Hydroxychlorpromazine
CAS No.	2095-62-7
Molecular Formula	C17H19ClN2OS
Molecular Weight	334.86 g/mol
Synonyms	7-Hydroxychlorpromazine; 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine 7-oxide; Chlorpromazine 7-oxide; Chlorpromazine Sulfoxide; Chlorpromazine Sulfoxide (7-OH); 7-Hydroxy CPZ; 7-OH-Chlorpromazine; NSC 71963
EINECS	Contact for details

Quality Control

Our 7-Hydroxychlorpromazine is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results from tests including HPLC assay, related substances, and spectroscopic identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.