Description

Clothiapine is a dibenzothiazepine derivative belonging to the class of atypical antipsychotic agents. This compound is of significant interest in pharmaceutical research and development due to its unique receptor binding profile. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) therapeutics and the study of neuropharmacology.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research for the development of novel antipsychotic medications.
• Biochemical Research: Employed in studies investigating dopamine and serotonin receptor interactions and their role in neurological pathways.
• Metabolite Studies: Utilized as a parent compound in pharmacokinetic and metabolic stability research.
• Analytical Testing: Acts as a high-purity standard for HPLC, LC-MS, and GC-MS analysis in forensic and clinical toxicology.

Basic Information

Product Name	Clothiapine
CAS No.	2058-52-8
Molecular Formula	C18H18ClN3S
Molecular Weight	343.87 g/mol
Synonyms	Clotiapine; Etumine; Deliton; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]thiazepine; HF-2159; W-801; Entumine; Azomepron
EINECS	218-164-7

Quality Control

Our Clothiapine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) containing batch-specific data from HPLC, NMR, and MS is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.