Description

Spiroperidol Hydrochloride CAS NO 2022-29-9 is a high-purity pharmaceutical reference standard and active pharmaceutical ingredient (API) belonging to the butyrophenone class of antipsychotics. It is critical for research, analytical method development, and quality control in the pharmaceutical industry. This compound is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on neuropharmacology and drug development.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of related drug substances and finished products in compliance with pharmacopeial methods (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API): Serves as the key therapeutic component in the formulation of antipsychotic medications for research and development purposes.
• Biochemical Research: Employed as a potent dopamine D2 receptor antagonist in neurological and psychiatric disorder studies, including schizophrenia and Tourette syndrome research.
• Analytical Chemistry: Acts as a critical calibrant and system suitability standard in High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) methods.
• Preclinical Studies: Utilized in animal models to investigate the pharmacokinetics, pharmacodynamics, and toxicological profiles of butyrophenone derivatives.

Basic Information

Product Name	Spiroperidol Hydrochloride
CAS No.	2022-29-9
Molecular Formula	C23H26FN3O2 • HCl
Molecular Weight	431.93 g/mol (as free base: 395.47 g/mol)
Synonyms	Spiperone Hydrochloride; Spiroperidol HCl; 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Hydrochloride; R 5147; R-5147; McN-JR-6218; Spiroperidolum Hydrochloride; Spiroperidol Hydrochloridum
EINECS	217-966-8

Quality Control

Our Spiroperidol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.