Description

2,4-Difluoro-1-Methoxybenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals where the introduction of fluorine atoms is required to modulate biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where fluorine substitution enhances efficacy and environmental stability.
• Liquid Crystal Materials: Serves as a core building block for fluorinated liquid crystals used in display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Chemical Research: A valuable reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution for introducing methoxy and fluoro groups.
• Dye and Pigment Industry: Intermediate for creating specialized fluorinated dyes with altered light absorption and stability properties.

Basic Information

Product Name	2,4-Difluoro-1-Methoxybenzene
CAS No.	252-10-8
Molecular Formula	C7H6F2O
Molecular Weight	144.12 g/mol
Synonyms	1,3-Difluoro-4-methoxybenzene; 2,4-Difluoroanisole; 4-Methoxy-1,3-difluorobenzene; p-Methoxy-m-difluorobenzene; 2,4-Difluorophenyl methyl ether; Anisole, 2,4-difluoro-
EINECS	205-978-7

Quality Control

Every batch of 2,4-Difluoro-1-Methoxybenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.470 - 1.474
Density (20°C)	1.22 - 1.26 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.