Description

tert-Butyl (3-Bromo-5-Methylbenzyl)Carbamate is a high-purity, synthetically valuable organic building block. This compound is a protected amine derivative, specifically a carbamate, which is essential for advanced pharmaceutical and agrochemical synthesis. It serves as a critical intermediate for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and other fine chemicals. The presence of both bromo and methyl substituents on the aromatic ring offers versatile sites for further functionalization via cross-coupling and other key organic transformations.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating libraries of compounds.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides, herbicides, and fungicides.
• Organic Synthesis Reagent: Serves as a versatile precursor for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Peptidomimetics & PROTACs: Employed in the construction of complex molecules like peptide mimics and proteolysis-targeting chimeras (PROTACs) for drug discovery.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced organic materials.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological mechanisms.

Basic Information

Product Name	tert-Butyl (3-Bromo-5-Methylbenzyl)Carbamate
CAS No.	1998726-82-1
Molecular Formula	C13H18BrNO2
Molecular Weight	300.19 g/mol
Synonyms	Boc-3-Bromo-5-methylbenzylamine; N-Boc-3-Bromo-5-methylbenzylamine; 1-[(tert-Butoxycarbonyl)amino]methyl]-3-bromo-5-methylbenzene; tert-Butyl N-[(3-bromo-5-methylphenyl)methyl]carbamate; Carbamic acid, N-[(3-bromo-5-methylphenyl)methyl]-, 1,1-dimethylethyl ester; (3-Bromo-5-methylbenzyl)carbamic acid tert-butyl ester; Boc-AMine-(3-Br-5-Me-Ph)
EINECS	Contact for details

Quality Control

Our tert-Butyl (3-Bromo-5-Methylbenzyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in GMP and ISO environments for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.