Description

1H-Pyrazole-3-Propanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-1-Methyl-, (αs)- is a specialized, high-purity Fmoc-protected amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. Its core value lies in providing a precisely engineered building block that enables the controlled introduction of a modified pyrazole side chain, which is critical for developing novel bioactive compounds and pharmaceutical intermediates. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors who require reliable, high-quality raw materials for drug discovery and process development. CAS No. 1998640-22-4.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a crucial building block for the automated synthesis of complex peptides containing non-proteinogenic residues.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new therapeutic agents, particularly for creating peptide-based drugs and peptidomimetics with enhanced stability or activity.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides used as tools to study protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Agrochemical Research: Applied in the development of novel peptide-inspired bioactive compounds for crop protection and agricultural science.
• Process Development & Scale-Up: Serves as a key intermediate for pharmaceutical companies scaling up the production of candidate drugs from laboratory to pilot plant and commercial manufacturing.

Basic Information

Product Name	1H-Pyrazole-3-Propanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-1-Methyl-, (αs)-
CAS No.	1998640-22-4
Molecular Formula	C22H21N3O4
Molecular Weight	391.42 g/mol
Synonyms	Fmoc-1-Me-3-(2-carboxyethyl)-1H-pyrazole-5-amine; (S)-Fmoc-1-methyl-1H-pyrazole-3-propanoic acid; Fmoc-1-methyl-1H-pyrazole-3-alanine; Fmoc-(1-Me-Pza(3))-OH; 1-Methyl-1H-pyrazole-3-propanoic acid, N-Fmoc derivative; α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1-methyl-1H-pyrazole-3-propanoic acid; Fmoc-1-methyl-3-(2-carboxyethyl)pyrazole-5-amine; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.